KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM17
All Species:
20.61
Human Site:
T142
Identified Species:
37.78
UniProt:
P78536
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78536
NP_003174.3
824
93021
T142
D
V
I
I
R
I
N
T
D
G
A
E
Y
N
I
Chimpanzee
Pan troglodytes
XP_001154844
807
90985
T142
D
V
I
I
R
I
N
T
D
G
A
E
Y
N
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532870
787
87680
F137
T
S
W
D
N
A
G
F
K
G
Y
G
I
Q
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0F8
827
93055
T142
D
V
T
V
R
I
N
T
D
G
A
E
Y
N
I
Rat
Rattus norvegicus
Q9Z1K9
827
92999
T142
D
V
T
V
R
I
N
T
D
G
A
E
Y
N
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516484
430
47905
Chicken
Gallus gallus
NP_001008682
829
93588
T143
D
F
T
V
R
I
N
T
D
G
E
E
Y
N
I
Frog
Xenopus laevis
Q8JIY1
749
84049
L130
S
K
G
L
L
K
P
L
K
A
H
S
Y
V
E
Zebra Danio
Brachydanio rerio
XP_689147
838
93831
T140
D
F
T
A
H
I
L
T
D
E
A
E
Y
N
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VAC5
732
83062
F117
S
F
Y
S
G
R
V
F
G
E
L
E
S
S
V
Honey Bee
Apis mellifera
XP_623993
716
82155
E101
Y
H
G
R
V
F
G
E
I
D
S
H
A
Q
M
Nematode Worm
Caenorhab. elegans
NP_509318
686
77280
T71
H
E
N
F
K
V
F
T
Q
D
G
P
Q
I
V
Sea Urchin
Strong. purpuratus
XP_790625
763
85522
I134
T
R
E
E
Q
Y
T
I
E
P
S
W
R
H
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
N.A.
68.6
N.A.
91.9
92.1
N.A.
48
76.4
28.5
61.4
N.A.
37.3
37.2
26.3
33.2
Protein Similarity:
100
97.9
N.A.
72
N.A.
96.3
96.3
N.A.
50
87.2
44.7
74.8
N.A.
54.2
53
43.4
51.5
P-Site Identity:
100
100
N.A.
13.3
N.A.
86.6
86.6
N.A.
0
73.3
6.6
60
N.A.
6.6
0
6.6
6.6
P-Site Similarity:
100
100
N.A.
13.3
N.A.
93.3
93.3
N.A.
0
80
13.3
60
N.A.
20
13.3
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
0
0
0
8
39
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
0
0
8
0
0
0
0
47
16
0
0
0
0
0
% D
% Glu:
0
8
8
8
0
0
0
8
8
16
8
54
0
0
8
% E
% Phe:
0
24
0
8
0
8
8
16
0
0
0
0
0
0
0
% F
% Gly:
0
0
16
0
8
0
16
0
8
47
8
8
0
0
0
% G
% His:
8
8
0
0
8
0
0
0
0
0
8
8
0
8
0
% H
% Ile:
0
0
16
16
0
47
0
8
8
0
0
0
8
8
62
% I
% Lys:
0
8
0
0
8
8
0
0
16
0
0
0
0
0
0
% K
% Leu:
0
0
0
8
8
0
8
8
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
8
0
8
0
39
0
0
0
0
0
0
47
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
8
0
8
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
8
0
0
0
8
16
0
% Q
% Arg:
0
8
0
8
39
8
0
0
0
0
0
0
8
0
0
% R
% Ser:
16
8
0
8
0
0
0
0
0
0
16
8
8
8
0
% S
% Thr:
16
0
31
0
0
0
8
54
0
0
0
0
0
0
0
% T
% Val:
0
31
0
24
8
8
8
0
0
0
0
0
0
8
16
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
8
0
8
0
0
8
0
0
0
0
8
0
54
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _